How Does Fentanyl Reach the United States?

How Does Fentanyl Reach the United States?

As fentanyl flows in from the south, the U.S. government has stepped up measures both at the border and beyond to curb the influx.
As fentanyl flows in from the south, the U.S. government has stepped up measures both at the border and beyond to curb the influx. Christian Torres/Anadolu/Getty Images

President Trump has imposed punitive measures on several countries in the name of curbing what he characterizes as high fentanyl flows into the United States. In reality, supplies of the drug—and related deaths—have sharply declined, though they are still at worrying levels.

Last updated November 21, 2025 9:51 am (EST)

As fentanyl flows in from the south, the U.S. government has stepped up measures both at the border and beyond to curb the influx.
As fentanyl flows in from the south, the U.S. government has stepped up measures both at the border and beyond to curb the influx. Christian Torres/Anadolu/Getty Images
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Current political and economic issues succinctly explained.

President Donald Trump has made combating fentanyl trafficking a core tenet of his foreign policy. In March 2025, he imposed sweeping tariffs on the United States’ three biggest trading partners—Canada, China, and Mexico—citing the “extraordinary threat” posed by fentanyl and the countries’ failure to prevent the drug’s flow into the United States. Since late October, the Trump administration has expanded efforts to combat fentanyl trafficking by conducting strikes against alleged Venezuelan drug boats and deploying U.S. military forces in the Latin American region.

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The opioid crisis has ravaged the United States for years, although fatalities have sharply declined since 2023. At the crisis’s peak in 2022, drug overdoses caused more than 111,000 fatalities per year, most of them driven by fentanyl. Fentanyl and synthetic opioids quickly rose to become the leading cause of death for Americans aged eighteen to forty-five. 

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China

Mexico

China and Mexico, where fentanyl and its precursors are produced and trafficked before entering the United States, have stepped up measures to contain the flow of the drug. Canada has done the same, despite being responsible for almost none of the fentanyl that winds up inside U.S. borders.

What is the status of the fentanyl crisis?

Notably, Americans are heavily involved in the fentanyl crisis, with U.S. citizens accounting for around 90 percent [PDF] of fentanyl trafficking convictions in recent years. Annual fentanyl-related deaths remain in the scores of thousands but are trending downward for the first time in years. Fatal overdoses have dropped nationwide by more than 21 percent since June 2023, data from the U.S. Centers for Disease Control and Prevention (CDC) shows. The death toll dipped below seventy-four thousand deaths in a twelve-month period ending in April 2025; while that’s still significantly high, it’s the lowest level seen since 2020. 

Experts say the decline is in large part due to concerted efforts by the Biden administration to curb trafficking in cooperation with other countries, namely China and Mexico.

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Despite this progress, the Trump administration has stressed that fentanyl levels remained too high. Trump pointed to the countries’ roles in trafficking fentanyl into the United States as a reason to impose tariffs, and has claimed that fentanyl deaths range anywhere from three hundred thousand per year to “tens of millions” of mortalities—figures that law enforcement and public health experts say are inaccurate.

How much of the U.S. illicit fentanyl supply comes from Canada, China, and Mexico?

Mexico

Mexico imports large amounts of fentanyl precursor chemicals via illicit networks set up by cartels, who then manufacture the drug before smuggling it across the U.S. border.  Fentanyl’s potency makes it easier to smuggle across borders undetected compared to some other drugs, as traffickers only need to transport small amounts. Mexico has long been the main source of fentanyl into the United States—nearly all of the 21,900 pounds that U.S. law enforcement seized last year was at the southern border, compared to only 43 pounds of fentanyl seized at the Canadian border, according to U.S. data. 

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Mexico

Mexico has been facing mounting pressure to clamp down on drug trafficking, prompting President Claudia Sheinbaum to increase government crackdowns on gangs.  The country made its biggest arrest of fentanyl traffickers ever in December. U.S. Drug Enforcement Administration (DEA) data indicated that the amount of fentanyl seized at the southern border last year dropped by around 20 percent.

China

China’s role in the fentanyl trade is a little more complicated. Beijing banned fentanyl and all potential fentanyl variants within its own borders in 2019 and maintains that it does not allow the manufacture of fentanyl. Chinese companies are widely known to make precursor chemicals, many of which have legitimate uses, principally in the medical sector. However, these precursors are often purchased by transnational criminal organizations in Mexico to synthesize fentanyl. 

For years, China has resisted tackling the supply chain of precursor chemicals, pointing to its own ban on the drug as alleged proof of its lack of contribution to the fentanyl issue. Beijing reached an agreement in 2024 with the Biden administration to impose tough new measures on precursor chemicals. The two sides also agreed to boost cooperation to stem drug trafficking, which U.S. officials say has helped hamper fentanyl’s flow into the United States. After a bilateral meeting in November, the United States announced it would lift a 10 percent tariff on Chinese goods in exchange for China’s commitment to halt the flow of precursors.

Canada

Canada plays virtually no role in the U.S. fentanyl influx, especially compared to the other countries targeted by the Trump administration. The country contributes less than 1 percent to its southern neighbor’s street fentanyl supply, according to both the Canadian government and the DEA. 

Venezuela

Trump has cited the drug trade, including fentanyl, as a major reason for ordering strikes on alleged drug boats off the coast of Venezuela, and for considering strikes on its land, too. He alleged that the targeted boats were “stacked up with bags of white powder, that’s mostly fentanyl.” Yet fentanyl itself is not produced or widely consumed in the Latin American country. 

The DEA estimates that around 74 percent of the cocaine that makes its way to the United States travels through the Pacific. Trump’s strikes on alleged drug boats have recently widened across the Pacific theater, including some Colombian vessels. 

How have these countries responded? 

The leaders of Canada and Mexico negotiated a pause on the enforcement of U.S.  tariffs and have since ramped up their antidrug measures. Canada unveiled a $1.3 billion plan to secure the border and appointed a fentanyl czar. Mexico announced that it would reinforce its border with another ten thousand National Guard troops aimed specifically at stopping fentanyl in its tracks. Venezuela denounced the U.S. military build-up and accused Trump of “fabricating a new war,” before announcing in November 2025 that it was mobilizing its own military in response.

The Chinese foreign ministry said in March that tariffs will actually undermine cooperation against drug trafficking, a concern U.S. experts have echoed. Trump’s pause of all foreign assistance halted anti-fentanyl work in Mexico, officials familiar with the matter told Reuters. Experts and regional leaders in the Caribbean, including Colombian President Gustavo Petro, have said U.S. boat strikes in the area are an ineffective way to combat drug trafficking. 

Austin Steinhart and Will Merrow contributed to the graphics for this article. 

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